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- Developing ex-vivo and in-vivo models of drug delivery in large animals such as pigs similar to humans.
- Developing extracellular vesicles as efficacious and safe carriers to deliver therapy-related substances to the inner ear.
- Identifying novel sensory receptors and channels of round window membrane that sense chemicals, investigating how receptors and channels regulate drug passage to the inner ear, and harnessing receptors and channels to improve inner ear drug delivery.
- In vivo and ex-vivo 3D high-resolution imaging for inner ear visualization, metabolomics, inflammation, and drug biodistribution.
- Evaluate promising regeneration therapy effects delivered safely in a clinically relevant animal model like pigs.
- Nanomaterials and smart materials to improve drug delivery to the inner ear.
